Search on: INSULIN DEGRADING ENZYME 
Descriptors Found: 1
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Descriptor English:   Insulysin 
Descriptor Spanish:   Insulisina 
Descriptor Portuguese:   Insulisina 
Synonyms English:   Insulin Protease
Insulin Proteinase
Insulin-Degrading Enzyme
Enzyme, Insulin-Degrading
Insulin Degrading Enzyme
Protease, Insulin
Proteinase, Insulin
Insulinase  
Tree Number:   D08.811.277.656.300.480.300
D08.811.277.656.675.374.300
Definition English:   An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56. 
History Note English:   97; was INSULINASE 1963-96 (see under PEPTIDE HYDROLASES 1975-90, see under ENDOPEPTIDASES 1963-74) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   7509 
Unique Identifier:   D007339 

Occurrence in VHL:
 

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